Frequently Asked Questions About WINREVAIR

PAH patients may experience symptoms such as shortness of breath, dizziness, fatigue, and chest pain. Some other PAH symptoms may include cough, swelling of the lower body, or a lack of energy.

The pulmonary arteries transport blood from the right side of the heart through the lungs to receive oxygen. In PAH patients, the walls of the pulmonary arteries thicken, narrowing the space where blood can flow. The right side of the heart has to work harder to pump blood through the lungs, leading to high blood pressure in the pulmonary arteries.

Over time, the right side of the heart can become weakened and lose function, resulting in less oxygen transported throughout the body.

WINREVAIR is a prescription medicine used to treat adults with pulmonary arterial hypertension (PAH). PAH is a type of high blood pressure in the arteries of your lungs. 

WINREVAIR can improve your ability to exercise, improve your ability to perform normal activities with fewer symptoms, and reduce the risk of your physical condition and symptoms worsening.

It is not known if WINREVAIR is safe and effective in children under 18 years of age.

Yes, WINREVAIR was approved by the FDA in March 2024. WINREVAIR is a prescription medicine for adults with pulmonary arterial hypertension (PAH). PAH is a type of high blood pressure in the arteries of your lungs. WINREVAIR can improve your ability to exercise, improve your ability to perform normal activities with fewer symptoms, and reduce the risk of your physical condition and symptoms worsening.

Talk to your healthcare provider about side effects and visit Possible Side Effects of WINREVAIR to learn more.

In the STELLAR clinical trial, adults with PAH (WHO Group 1, functional class II or III) added either WINREVAIR or placebo to the PAH medicines they were already taking. Almost all patients in the trial (96%) were already taking 2 or 3 PAH medicines before adding WINREVAIR or placebo. Visit Clinical Trial Results to learn more. Talk to your doctor to learn more about WINREVAIR.

WINREVAIR was studied in adult patients in a clinical trial called STELLAR. Visit Clinical Trial Results to learn more about this study. Talk to your doctor to learn more about WINREVAIR.

You or your healthcare provider should report any exposure to WINREVAIR during pregnancy or breastfeeding by calling 1-877-888-4231.

Research shows that PAH patients have high levels of a protein called activin that signals new cells to form. Too much activin creates an imbalance in signaling, which causes cells to multiply and build up in the walls of the pulmonary arteries. WINREVAIR directly targets excess activin and blocks its signals. By blocking excess activin signals, WINREVAIR helps control cell growth. Visit How WINREVAIR Works to learn more.

Most PAH medicines work on one of three well-known treatment pathways. WINREVAIR works on a unique, fourth treatment pathway: the activin signaling pathway. Visit How WINREVAIR Works to learn more.

Yes. You can find more information, including the Instructions for Use Videos (1-vial kit, 2-vial kit) and the detailed Instructions for Use booklet (1-vial kit, 2 vial kit) on the Taking WINREVAIR page.

Your prescribed dose in milliliters (mL) is on your prescription label on your kit. Contact your healthcare provider if you cannot find your prescribed dose.

Place a cotton ball or bandage on your skin right away and apply a small amount of pressure. If the bleeding does not stop, call your healthcare provider right away. 

Yes. There is a chance that your dose could change. Your healthcare provider will tell you how much WINREVAIR to inject and when to inject it. This is because your prescribed dose depends on your body weight and blood tests.

Wash the area thoroughly with soap and water right away. 

Call your pharmacy or healthcare provider.

Do not worry if your plunger moves slightly on its own when you are filling your dosing syringe with medicine. 

With one hand, hold the plunger in place to stop the plunger from moving. With the other hand, unscrew the vial from the dosing syringe. After it is unscrewed, it is safe to let go of the plunger. 

You can avoid this automatic plunger movement by pushing air into the vial before filling your dosing syringe with medicine. Refer to the Instructions for Use Videos and the Instructions for Use booklet (1-vial kit, steps 16-23; 2-vial kit, steps 17-28) on the Taking WINREVAIR page for detailed instructions.

Do not use your kit. Call your pharmacy to get a new kit.

Do not use the medicine if you have swirled the medicine vial for about 2 minutes and let it stand for another 3 minutes but your medicine vial remains cloudy or has clumps, powder, or foreign particles. 

Call your pharmacy to get a new kit.

Check that the vial adapter is attached to the vial securely. If not, hold the vial and press the vial adapter down firmly to make sure the vial adapter punctures the vial rubber stopper.

Do not use if any items are damaged. If you are unsure, call your pharmacy to get a new kit.

Store the injection kit in the refrigerator until ready to use it. If the unused injection kit has been out of the refrigerator up to 77°F (25°C) for more than 24 hours, please contact your pharmacy or healthcare provider.

We recommend you inject the medicine right away after mixing, but no later than 4 hours after mixing. If it has been more than 4 hours, throw away the unused mixed medicine. 

If you have questions, please contact your pharmacy or healthcare provider.

If you have questions about how to give WINREVAIR the correct way or need more information, you can call your pharmacy or healthcare provider. You can also watch the Instructions for Use videos.

Store vials refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. Do not freeze.